- Random drop from act bosses.
- Each act boss drop a specific artifact.
|5||Karp King||Karp King's Belly Button||*Not required for Fallen Inoya|
|6||Satan||Satan's Horn||*Not required for Fallen Inoya|
|7||Mevius||*No Prime Evil Artifact|
- Dropchance is 28% at Inferno and 35% at Agony difficulty, and 45% on Destruction.
- Spend a full set of this artifacts to Um in Town of Inoya to summon the portal to Fallen Inoya
Gurag's Heart, Damien's Eye, Karp King's Belly Button
Death's Sigil, Anubis' Ankh, Satan's Horn